Cannabis mitigates the symptoms of Crohn’s disease

Cannabis mitigates the symptoms of Crohn’s disease

 

Cannabis, for the mitigation of symptoms of Crohn’s disease. The evidence presented in the occasion of the European congress of gastroenterology in Viena, is preliminary, but of great interest for the scientific community and the public opinion.

Enfermedad de Crohn

Crohn’s disease is a chronic intestinal inflammation, which can affect the entire gastrointestinal tract.  The symptoms characterizing this disease are abdominal pain, chronic diarrhoea, weight loss and fever.

El exámenes permitting a correct diagnosis are: colonoscopy, histological examination, abdominal and intestinal echography with radiography of the small intestine, CT enteroclysis or abdominal magnetic resonance.

The study conducted in Israel

The first study of this kind was conducted at the Meir Hospital of Tel Aviv  and involved 46 patients affected by Enfermedad de Crohn in severe and moderate forms, treated with immunosuppressive or biological medicines.

The patients were divided in two groups, the first was treated with a placebo solution, while the second one with oil containing 15% CDB and 4% THC.
The study lasted for eight weeks, during which the symptoms of the patients were monitored, as well as possible variations of their quality of life.

Those consuming the oil showed a reduction of the symptoms of the disease, in over six cases out of ten remission of the disease was observed. Symptoms, like abdominal pain, diarrhoea and sense of fatigue had disappeared.

Crohn’s disease is characterized by a severe inflammatory process, which is contrasted but not reduced. The researchers came to this conclusion through a colonoscopy and the assay of specific markers.

Timna Naftali, gastroenterologist, who conducted the research team, presented the results of the study in Vienna:

“We’ve demonstrated that cannabis can produce a measurable improvement of the symptoms of Crohn’s disease, but, surprisingly, these are not detected at intestinal level or through the indicators of the inflammation”.

An element of surprise as cannabinoids can have an anti-inflammatory effect, which in this case has not emerged.

Hence, according to the experts, as at today, for Chron’s disease cannabis is an additional therapy to give relief and a better quality of life.

CBD (Cannabidiol), ¿después de cuánto tiempo comienza a actuar?

El tiempo que tarda el CBD en actuar, en general, está relacionado con los modos de consumo.

Metabolismo de CDB, being  involved in many physiological processes as a modulator of other systems, and not just the endocannabinoids system, is extremely subjective.

Este es un elemento a tener en cuenta para estimar el tiempo necesario para que el cannabidiol comience a actuar.

Sin embargo, podemos afirmar que si tomamos CDB  por vía sublingual, en forma de aceite, por ejemplo, o por inhalación, por vaporización cristales, evitamos el paso por el tracto gastrointestinal, y habrá un efecto estimado en unos quince minutos.

Si, por el contrario, consumimos CBD en cápsulas, lo que implica un paso por el estómago, el “tiempo de efecto” será más largo y según las enzimas involucradas, ¡puede variar de una a tres horas!

¿Cuáles son los posibles efectos secundarios del CBD?

Un efecto "secundario" podría ser una sequedad excesiva de la boca, que es causada por los receptores cannabinoides presentes en las glándulas submandibulares, que son responsables de la producción de saliva.

La activación de estos receptores altera la producción de saliva, provocando sequedad de boca.

Un segundo efecto "secundario" del cannabidiol es una excesiva estado de relajación , por lo tanto de presunta somnolencia.

En este caso, se recomienda, al tomar CBD por primera vez, comenzar con pequeñas cantidades y luego calibrar en función de las propias necesidades.

Alto consumo de CDB could create an effect of dizziness, possibly associated with a drop in blood pressure.

In this case it could be enough to drink a tea to make this unpleasant effect disappear.

En dosis aún más altas, el CBD podría causar somnolencia, la recomendación es evitar conducir o hacer cosas que requieran una concentración especial.

 

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