CBD is a molecule with very interesting characteristics, with the support of the conducted studies, we will analyse five fields in which cannabidiol would show to be effective.
1 - Insomnia
CDB due to its neuroprotectant potential, based on the combination of its anti-inflammatory and antioxidant effects, could reveal useful, for example, in contrasting insomnia.
A study published in 2017 “Cannabis, cannabinoides y sueño: una revisión de la literatura”, demonstrates how cannabidiol (CBD) could have a therapeutic potential in favouring good quality of sleep.
Sleep latency is ‘measured’ by a prueba, which takes place an hour and a half, three hours after nocturnal sleep, in which the patient, in a quiet, dark environment with a constant temperature, is invited to fall asleep four - five times at a two hour interval.
The test is concluded 15 minutes after the patients falls asleep or after having tried for 20 minutes to fall asleep without succeeding. Sleep latency, reproduced several times, below 5 minutes is pathological, between 5 and 10 minutes is within the limit values.
“Delta-9 Tetrahydrocannabinol (THC) can reduce sleep latency, but also compromises the quality of sleep in the long-term”.
2 - Acne
Acne is an inflammation of the sebaceous glands which could be contrasted by CBD.
According to a study published in the Journal of Clinical Investigation entitled “Cannabidiol exerts sebostatic and anti-inflammatory effects on human sebocytes” cannabidiol would contribute to the decrease of sebum production which leads to acne, thanks to its anti-inflammatory properties.
3 - Epilepsy
CBD is an important ally with which to fight epilepsy, especially in cases of drug-resistant children.
“Numerous scientific studies have been carried out on CBD, and with more than well-founded reasons – Profesor Pasquale Striano states, Doctor in Paediatric Neurology and Muscular Affections at the ”G.Gaslini” in Genoa – It has been demonstrated in several occasions, both anecdotally and clinically, that positive effects on a wide range of health conditions exist. One of the medical fields in which CBD shows to have the best results are related to cases of epilepsy, in its most severe form.
In the United Stated, the first medical drug created with cannabis extracts has been approved, with which it will be possible to treat some forms of epilepsia.
4 - Psoriasis
La psoriasis es una inflamación crónica de la piel, no contagiosa ni infecciosa.
Por lo general, la psoriasis se manifiesta como áreas con erupción, caracterizadas por manchas rojas con escamas plateadas, causadas por un engrosamiento anormal de la capa córnea de la piel.
Las zonas del cuerpo que en general se ven más afectadas son codos, rodillas, manos, coxis, cuero cabelludo y pies.
The causes can be linked to factors like genetics or can be environmental, can regard emotional and physical aspects, in certain cases also caused by the use of medical drugs. A lifestyle characterized by smoking, alcohol, obesity, stress and an improper diet certainly favours psoriasis.
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5 - Bone fracturas
According to data emerged from a study conducted in 2015 by the Bone Laboratory of the Hebrew University in Jerusalem, involving mice with femoral fractures, CBD would support an increased recovery of the biomechanical characteristics of the bones after a therapy of eight weeks.
El estudio de la Universidad Hebrea de Jerusalén
"El cannabidiol, un componente importante del cannabis no psicotrópico, mejora la curación de las fracturas y estimula la actividad de la lisil hidroxilasa en los osteoblastos" es el título de la publicación en la que se demuestra cómo “el principal componente no psicotrópico del cannabis es el cannabidiol (CBD)”.
Durante las ocho semanas de investigación, los ratones se dividieron en grupos y se trataron con diferentes tipos de terapias.
A first group was treated with CBD and THC, the two cannabinoids working in synergy, but did not show significant results in the improvement of bone fractures.
According to the researchers the most interesting results were obtained when CBD acting “alone” was observed.
“..cannabidiol (CBD), improves the biomechanical properties of healing mid-femoral fractures in rats. The maximal load and work-to-failure, but not the stiffness, of femurs of rats treated with a mixture of CBD and THC for 8 weeks, were markedly increased by CBD”.
El CBD resulta eficaz para mejorar la reticulación del colágeno, una proteína muy importante, que permite mejorar las propiedades biomecánicas del callo, que se forma después de la reparación de la fractura.
The mice, divided in three groups, demonstrated promising ‘general’ results, as the researchers discovered how CBD could increase the mRNA levels of lysine hydroxylation, which is involved in the formation of bridging across the fracture gap. Hence, Cannabidiol would have a beneficial effect not only on the specific fracture but also on other components of the organism.
Cannabinoides y dolor de contraste en enfermedades óseas
Arthritis is a bone pathology, which literally means “painful joints”. It can have different forms and features and is a term with which a macro-category is indicated in which over 200 diseases exist.
Un estudio realizado en el Parque de las Ciencias de Oxford, published in Rheumatology in 2005 examined patients affected by rheumatoid arthritis, to whom a Cannabis extract was administered containing mainly THC and CDB.
Después de cinco semanas de tratamiento los pacientes reportaron una mejora significativa en cuanto al dolor y la movilidad y, además, una mejora significativa en la calidad del sueño.
Un estudio más reciente, "El cannabidiol, constituyente no psicoactivo del cannabis, es un tratamiento antiartrítico oral en la artritis inducida por colágeno murino" evalúa el papel del CBD en el tratamiento de esta patología. Tomado por vía oral, el cannabidiol contribuiría a calmar el dolor causado por la artritis.
“La dosis mostró una curva en forma de campana, con un efecto óptimo a 25 mg / kg diarios, por vía oral. La mejoría clínica se ha asociado a la protección de las articulaciones frente a daños graves ”.
El CBD, debido a sus acciones inmunosupresoras y antiinflamatorias combinadas, tiene un fuerte efecto antiartrítico.